Characterization, Anti-lung Cancer Activity, and Cytotoxicity of Bio-synthesized Copper Nanoparticles by Thymus fedtschenkoi Leaf Extract
Today propose diverse techniques to remedy cancer and nanotechnology is one of the most
effective cancer treatments. In this study, we detail a simple and environmentally friendly …
effective cancer treatments. In this study, we detail a simple and environmentally friendly …
The hypervariable region of K-Ras4B governs molecular recognition and function
H Abdelkarim, A Banerjee, P Grudzien… - International journal of …, 2019 - mdpi.com
The flexible C-terminal hypervariable region distinguishes K-Ras4B, an important proto-
oncogenic GTPase, from other Ras GTPases. This unique lysine-rich portion of the protein …
oncogenic GTPase, from other Ras GTPases. This unique lysine-rich portion of the protein …
Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces …
KRAS mutations are the most common oncogenic mutations in lung adenocarcinoma in
Black Americans. Polyisoprenylated Cysteinyl amide Inhibitors (PCAIs) constitute a group of …
Black Americans. Polyisoprenylated Cysteinyl amide Inhibitors (PCAIs) constitute a group of …
Haimufang decoction, a Chinese medicine formula for lung cancer, arrests cell cycle, stimulates apoptosis in NCI-H1975 cells, and induces M1 polarization in RAW …
WP Ma, SM Hu, YL Xu, HH Li, XQ Ma, BH Wei… - … medicine and therapies, 2020 - Springer
Background Lung cancer has the highest morbidity and mortality in the world and novel
treatment strategies are still needed. Haimufang decoction (HMF) is a patented clinical …
treatment strategies are still needed. Haimufang decoction (HMF) is a patented clinical …
Activation of MAP Kinase Pathway by Polyisoprenylated Cysteinyl Amide Inhibitors Causes Apoptosis and Disrupts Breast Cancer Cell Invasion
JMS Lazarte, NS Lamango - Biomedicines, 2024 - mdpi.com
Prognoses for TNBC remain poor due to its aggressive nature and the lack of therapies that
target its “drivers”. RASA1, a RAS-GAP or GTPase-activating protein whose activity inhibits …
target its “drivers”. RASA1, a RAS-GAP or GTPase-activating protein whose activity inhibits …
[HTML][HTML] Two GEO MicroRNA expression profile based high-throughput screen to identify microRNA-31-3p regulating growth of medullary thyroid carcinoma cell by …
M Jiang, X Shi, H Zhu, W Wei, J Li - Medical science monitor …, 2019 - ncbi.nlm.nih.gov
Background Medullary thyroid carcinoma (MTC), a rare type of thyroid cancer, is a big
challenge in clinical treatment. However, the pathogenesis of MTC remains poorly …
challenge in clinical treatment. However, the pathogenesis of MTC remains poorly …
Synthetic Optimization and MAPK Pathway Activation Anticancer Mechanism of Polyisoprenylated Cysteinyl Amide Inhibitors
N Tawfeeq, Y Jin, NS Lamango - Cancers, 2021 - mdpi.com
Simple Summary RAS G-protein genes are frequently mutated and drive the progression of
about 30% of human cancers. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) offer a …
about 30% of human cancers. Polyisoprenylated cysteinyl amide inhibitors (PCAIs) offer a …
Polyisoprenylated cysteinyl amide inhibitors: a novel approach to controlling cancers with hyperactive growth signaling
NS Lamango, AT Nkembo, E Ntantie… - Current medicinal …, 2021 - benthamdirect.com
Aberrant activation of monomeric G-protein signaling pathways drives some of the most
aggressive cancers. Suppressing these hyperactivities has been the focus of efforts to obtain …
aggressive cancers. Suppressing these hyperactivities has been the focus of efforts to obtain …
[PDF][PDF] Synthetic Optimization and MAPK Pathway Activation Anticancer Mechanism of Polyisoprenylated Cysteinyl Amide Inhibitors. Cancers (Basel). 2021; 13: 5757
N Tawfeeq, Y Jin, NS Lamango - 2021 - pdfs.semanticscholar.org
Abnormalities of the MAPK pathway play vital roles in cancer initiation and progression. RAS
GTPases that are key upstream mediators of the pathway are mutated in 30% of human …
GTPases that are key upstream mediators of the pathway are mutated in 30% of human …
Targeting KRAS Mutant Cancers with Polyisoprenylated Cysteinyl Amide Inhibitors
N Tawfeeq - 2021 - search.proquest.com
Abnormalities of the MAPK pathway play vital roles in cancer initiation and progression. RAS
GTPases that are key upstream mediators of the pathway are mutated in 20%–30% of …
GTPases that are key upstream mediators of the pathway are mutated in 20%–30% of …