Immunotherapy is being increasingly recognized as a key therapeutic modality to treat
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

Inhibitors of the Programmed Cell Death 1: Programmed Cell Death 1 ligand 1 (PD-1: PD-
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …

Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …

Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells.
In this study, we document parallel regulation of CD8+ T cells and Foxp3+ Tregs by …

The dramatic success of tyrosine kinase inhibitors (TKIs) has led to the widespread
perception that chronic myeloid leukemia (CML) has become another chronic disease …

The immune response plays an important role in staving off cancer; however, mechanisms
of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or …

Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …

The large family of costimulatory molecules plays a crucial role in regulation of the immune
response. These molecules modulate TCR signalling via phosphorylation cascades. Some …

Hepatitis B virus (HBV) infection is the major cause of inflammatory liver disease, of which
the clinical recovery and effective anti-viral therapy is associated with the sustained viral …