Tim‐3 and its role in regulating anti‐tumor immunity
M Das, C Zhu, VK Kuchroo - Immunological reviews, 2017 - Wiley Online Library
Immunotherapy is being increasingly recognized as a key therapeutic modality to treat
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
CD8 T cell exhaustion during chronic viral infection and cancer
LM McLane, MS Abdel-Hakeem… - Annual review of …, 2019 - annualreviews.org
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
Overcoming T cell exhaustion in infection and cancer
Inhibitors of the Programmed Cell Death 1: Programmed Cell Death 1 ligand 1 (PD-1: PD-
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
Resistance to tyrosine kinase inhibitors in chronic myeloid leukemia—from molecular mechanisms to clinical relevance
Simple Summary Chronic myeloid leukemia (CML) is a myeloproliferative neoplasia
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …
associated with a molecular alteration, the fusion gene BCR-ABL1, that encodes the tyrosine …
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
J Duraiswamy, KM Kaluza, GJ Freeman, G Coukos - Cancer research, 2013 - AACR
Tumor progression is facilitated by regulatory T cells (Treg) and restricted by effector T cells.
In this study, we document parallel regulation of CD8+ T cells and Foxp3+ Tregs by …
In this study, we document parallel regulation of CD8+ T cells and Foxp3+ Tregs by …
Moving treatment-free remission into mainstream clinical practice in CML
The dramatic success of tyrosine kinase inhibitors (TKIs) has led to the widespread
perception that chronic myeloid leukemia (CML) has become another chronic disease …
perception that chronic myeloid leukemia (CML) has become another chronic disease …
[HTML][HTML] Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
K Sakuishi, L Apetoh, JM Sullivan… - The Journal of …, 2010 - ncbi.nlm.nih.gov
The immune response plays an important role in staving off cancer; however, mechanisms
of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or …
of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or …
The chronic myeloid leukemia stem cell: stemming the tide of persistence
TL Holyoake, D Vetrie - Blood, The Journal of the American …, 2017 - ashpublications.org
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
[HTML][HTML] Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer
C Granier, E De Guillebon, C Blanc, H Roussel… - ESMO open, 2017 - Elsevier
The large family of costimulatory molecules plays a crucial role in regulation of the immune
response. These molecules modulate TCR signalling via phosphorylation cascades. Some …
response. These molecules modulate TCR signalling via phosphorylation cascades. Some …
T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance
Hepatitis B virus (HBV) infection is the major cause of inflammatory liver disease, of which
the clinical recovery and effective anti-viral therapy is associated with the sustained viral …
the clinical recovery and effective anti-viral therapy is associated with the sustained viral …