In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Despite successful clot retrieval in large vessel occlusion stroke,∼ 50% of patients have an
unfavorable clinical outcome. The mechanisms underlying this functional reperfusion failure …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

This review outlines the features of tandem regulation of glomerular microcirculation by
autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points …

Characterizing blood flow dynamics in vivo is critical to understanding the function of the
vascular network under physiological and pathological conditions. Existing methods for …

Recanalization is the mainstay of ischemic stroke treatment. However, even with timely clot
removal, many stroke patients recover poorly. Leptomeningeal collaterals (LMCs) are pial …

By converting physical forces into electrical signals or triggering intracellular cascades,
stretch-activated ion channels allow the cell to respond to osmotic and mechanical stress …

Leptomeningeal collaterals (LMCs) connect the main cerebral arteries and provide
alternative pathways for blood flow during ischaemic stroke. This is beneficial for reducing …

Microvascular networks feature a complex topology with multiple bifurcating vessels.
Nonuniform partitioning (phase separation) of red blood cells (RBCs) occurs at diverging …

Cortical microinfarcts are linked to pathologies like cerebral amyloid angiopathy and
dementia. Despite their relevance for disease progression, microinfarcts often remain …