Gene regulation in the immune system by long noncoding RNAs

YG Chen, AT Satpathy, HY Chang - Nature immunology, 2017 - nature.com
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …

Potential of long non‐coding RNAs in cancer patients: from biomarkers to therapeutic targets

S Chandra Gupta… - International journal of …, 2017 - Wiley Online Library
Because of high specificity and easy detection in the tissues, serum, plasma, urine and
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …

Long non-coding RNAs and complex diseases: from experimental results to computational models

X Chen, CC Yan, X Zhang, ZH You - Briefings in bioinformatics, 2017 - academic.oup.com
LncRNAs have attracted lots of attentions from researchers worldwide in recent decades.
With the rapid advances in both experimental technology and computational prediction …

LncRNA: a link between RNA and cancer

G Yang, X Lu, L Yuan - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

Revealing protein–lncRNA interaction

F Ferre, A Colantoni… - Briefings in …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of
which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs …

RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts

S Geisler, J Coller - Nature reviews Molecular cell biology, 2013 - nature.com
The increased application of transcriptome-wide profiling approaches has led to an
explosion in the number of documented long non-coding RNAs (lncRNAs). While these new …

Long non-coding RNAs: a new frontier in the study of human diseases

X Shi, M Sun, H Liu, Y Yao, Y Song - Cancer letters, 2013 - Elsevier
With the development of whole genome and transcriptome sequencing technologies, long
noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that …

Genome regulation by long noncoding RNAs

JL Rinn, HY Chang - Annual review of biochemistry, 2012 - annualreviews.org
The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …

LncRNAs in cancer: regulatory and therapeutic implications

A Nandwani, S Rathore, M Datta - Cancer letters, 2021 - Elsevier
Long noncoding RNAs (lncRNAs) comprise a class of RNAs that do not code for proteins but
are critical in regulating diverse cellular processes and maintaining cell function. In doing so …

Non-coding RNAs: the new central dogma of cancer biology

PE Saw, X Xu, J Chen, EW Song - Science China Life Sciences, 2021 - Springer
The central dogma of molecular biology states that the functions of RNA revolve around
protein translation. Until the last decade, most researches were geared towards …