Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical
technique being increasingly applied to a wide variety of problems. As the HDX-MS …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Chemistry” on HDX MS. 1 That review covered HDX MS applications from January 2012
through June 2014 and described the publications in terms of sector, geography, and topic …

Mass spectrometry (MS) is increasingly being used to probe the structure and dynamics of
proteins and the complexes they form with other macromolecules. There are now several …

Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

The study of drug–protein interactions can reveal the corresponding binding mechanisms,
providing valuable information for the early phase drug development and development of …

Despite the boom in biologics over the past decade, the intrinsic instability of these large
molecules poses significant challenges to formulation development. Almost half of all …

Summary Modular SCF (SKP1-CUL1-Fbox) ubiquitin E3 ligases orchestrate multiple cellular
pathways in eukaryotes. Their variable SKP1-Fbox substrate receptor (SR) modules enable …

Histone post-translational modifications (PTMs) are one of the main mechanisms of
epigenetic regulation. Dysregulation of histone PTMs leads to many human diseases, such …