Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

The process of entering the bloodstream, intravasation, is a necessary step in the
development of distant metastases. The focus of this review is on the pathways and …

Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …

The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

The disturbance of apoptosis molecular signaling pathways is involved in carcinogenesis.
BCL2 family of proteins is the hallmark of apoptosis regulation. In the last decade, new …

Background Osteosarcoma (OS) is a malignant tumor mainly occurring in young people.
Due to the limited effective therapeutic strategies, OS patients cannot achieve further …

Lymphoblastic lymphoma is a rare aggressive neoplasm of T‐/B‐precursors resembling
acute lymphoblastic leukemia, with no or limited bone marrow involvement (< 25%), that …

Zebrafish studies in the past two decades have made major contributions to our
understanding of hematopoiesis and its associated disorders. The zebrafish has proven to …

Traditional methods of cancer treatment are limited in their efficacy due to both inherent and
acquired factors. Many different studies have shown that the generation of ceramide in …

Hematopoietic stem cells (HSCs) have reduced capacities to properly maintain and
replenish the hematopoietic system during myelosuppressive injury or aging. Expanding …