Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved
macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for …

We report here chemoenzymatic and fully synthetic methodologies to modify aspartate and
glutamate side chains with ADP-ribose at specific sites on peptides. Structural analysis of …

The nonstructural protein 3 (NSP3) macrodomain of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(Mac1) removes adenosine diphosphate (ADP) ribosylation …

Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains
limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP …

PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with
relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating …

The emergence of several zoonotic viruses in the last twenty years, especially the pandemic
outbreak of SARS-CoV-2, has exposed a dearth of antiviral drug therapies for viruses with …

Background: Open Access Perspective The Conserved Macrodomain Is a Potential
Therapeutic Target for Coronaviruses and Alphaviruses by Anthony KL Leung 1, 2, 3, 4 …

Abstract The Coronavirus Disease 2019 (COVID-19) pandemic is still wreaking havoc
worldwide. Therefore, the urgent need for efficient treatments pushes researchers and …

Deep learning's automatic feature extraction has been a revolutionary addition to
computational drug discovery, infusing both the capabilities of learning abstract features and …