Ion channels and transporters typically consist of biomolecules that play key roles in a large
variety of physiological and pathological processes. Traditional therapies include many ion …

Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Onion consumption has been reported to be associated with a lower incidence of
myocardial infarction and stroke. Quercetin found in onions may contribute to this effect. This …

Armadillo repeat-containing proteins (ARMCs) are widely distributed in eukaryotes and have
important influences on cell adhesion, signal transduction, mitochondrial function regulation …

The impact of aging on vascular function is heterogeneous depending on the vascular
territories. Calcium regulation plays a key role in vascular function and has been implicated …

Heart failure is invariably associated with cardiac hypertrophy and impaired cardiac
performance. Although several drugs have been developed to delay the progression of …

MicroRNAs (miRNAs) have been regarded as modulators in vascular pathologies, including
hypertension. Dysregulated proliferation and migration of VSMCs (vascular smooth muscle …

Aim The purpose of this study was to investigate the mechanical and electrophysiological
effects of emodin on BK channels in the IRASMCs, of the rat. Methods Isolated interlobar …

Various heart diseases such as genetically-determined heart failure, acute myocardial
infarction, ischemia-reperfusion injury and catecholamine-induced cardiomyopathies are …

The role of STIM/Orai calcium entry system on vascular ageing has not been elucidated. We
aimed to evaluate the influence of ageing on STIM/Orai signalling and its role on ageing …