Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be
defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next …

▪ Abstract The forebrain comprises an intricate set of structures that are required for some of
the most complex and evolved functions of the mammalian brain. As a reflection of its …

Abstract Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency (IGD) IGD is a
genetically and clinically heterogeneous disorder. Mutations in many different genes are …

Idiopathic hypogonadotropic hypogonadism (IHH) due to defects of gonadotropin-releasing
hormone (GnRH) secretion and/or action is a developmental disorder of sexual maturation …

Congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS) are rare,
related diseases that prevent normal pubertal development and cause infertility in affected …

This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

Gonadotrophin‐releasing hormone‐1 (GnRH‐1) is essential for mammalian reproduction,
controlling release of gonadotrophins from the anterior pituitary. GnRH‐1 neurones migrate …

GnRH neurons follow a carefully orchestrated journey from their birth in the olfactory
placode area. Initially, they migrate along with the vomeronasal nerve into the brain at the …

The neuroendocrine control of reproduction in mammals is governed by a neural
hypothalamic network of nearly 1500 gonadotropin-releasing hormone (GnRH) secreting …