Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Parkinson disease (PD) is the second most common age-related neurodegenerative
condition diagnosed in North America. We recently demonstrated, using multiple …

Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor
dysfunction. Aging is the greatest risk factor for developing PD. Recent molecular genetic …

Fueled by aging populations and continued environmental contamination, the global burden
of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases …

Background An understanding of the genetic mechanisms underlying diseases in
ancestrally diverse populations is an important step towards development of targeted …

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …

Although over 90 independent risk variants have been identified for Parkinson's disease
using genome-wide association studies, most studies have been performed in just one …

Background Parkinson's disease (PD) is a neurodegenerative disease with an often
complex component identifiable by genome‐wide association studies. The most recent large …

Background Human genetics research lacks diversity; over 80% of genome‐wide
association studies have been conducted on individuals of European ancestry. In addition to …