The interneuron energy hypothesis: implications for brain disease
O Kann - Neurobiology of disease, 2016 - Elsevier
Fast-spiking, inhibitory interneurons–prototype is the parvalbumin-positive (PV+) basket cell–
generate action potentials at high frequency and synchronize the activity of numerous …
generate action potentials at high frequency and synchronize the activity of numerous …
Update on the mechanisms and roles of high‐frequency oscillations in seizures and epileptic disorders
High‐frequency oscillations (HFO s) are a type of brain activity that is recorded from brain
regions capable of generating seizures. Because of the close association of HFO s with …
regions capable of generating seizures. Because of the close association of HFO s with …
The pilocarpine model of mesial temporal lobe epilepsy: Over one decade later, with more rodent species and new investigative approaches
M Lévesque, G Biagini, M de Curtis… - Neuroscience & …, 2021 - Elsevier
Fundamental work on the mechanisms leading to focal epileptic discharges in mesial
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …
temporal lobe epilepsy (MTLE) often rests on the use of rodent models in which an initial …
The repertoire of seizure onset patterns in human focal epilepsies: determinants and prognostic values
Objective In this study, we seek to analyze the determinants of the intracranial
electroencephalography seizure onset pattern (SOP) and the impact of the SOP in predicting …
electroencephalography seizure onset pattern (SOP) and the impact of the SOP in predicting …
Computational models of epileptiform activity
We reviewed computer models that have been developed to reproduce and explain
epileptiform activity. Unlike other already-published reviews on computer models of …
epileptiform activity. Unlike other already-published reviews on computer models of …
An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy
Y Wang, Z Chen - Pharmacology & therapeutics, 2019 - Elsevier
Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …
understanding of the mechanism of the epilepsies has advanced greatly in the last three …
A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …
Dysregulation of GABAergic signaling in neurodevelomental disorders: targeting cation-chloride co-transporters to re-establish a proper E/I balance
The construction of the brain relies on a series of well-defined genetically and experience-or
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …
activity-dependent mechanisms which allow to adapt to the external environment. Disruption …
Specific imbalance of excitatory/inhibitory signaling establishes seizure onset pattern in temporal lobe epilepsy
M Avoli, M De Curtis, V Gnatkovsky… - Journal of …, 2016 - journals.physiology.org
Low-voltage fast (LVF) and hypersynchronous (HYP) patterns are the seizure-onset patterns
most frequently observed in intracranial EEG recordings from mesial temporal lobe epilepsy …
most frequently observed in intracranial EEG recordings from mesial temporal lobe epilepsy …
Parvalbumin-positive inhibitory interneurons oppose propagation but favor generation of focal epileptiform activity
Parvalbumin (Pv)-positive inhibitory interneurons effectively control network excitability, and
their optogenetic activation has been reported to block epileptic seizures. An intense activity …
their optogenetic activation has been reported to block epileptic seizures. An intense activity …