Obsessive-compulsive disorder: puzzles and prospects
Obsessive-compulsive disorder is a severe and disabling psychiatric disorder that presents
several challenges for neuroscience. Recent advances in its genetic and developmental …
several challenges for neuroscience. Recent advances in its genetic and developmental …
The mediodorsal thalamus: an essential partner of the prefrontal cortex for cognition
S Parnaudeau, SS Bolkan, C Kellendonk - Biological psychiatry, 2018 - Elsevier
Deficits in cognition are a core feature of many psychiatric conditions, including
schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome …
schizophrenia, where the severity of such deficits is a strong predictor of long-term outcome …
Distinct subcortical volume alterations in pediatric and adult OCD: a worldwide meta-and mega-analysis
PSW Boedhoe, L Schmaal, Y Abe… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: Structural brain imaging studies in obsessive-compulsive disorder (OCD) have
produced inconsistent findings. This may be partially due to limited statistical power from …
produced inconsistent findings. This may be partially due to limited statistical power from …
Orbitofrontal and striatal circuits dynamically encode the shift between goal-directed and habitual actions
Shifting between goal-directed and habitual actions allows for efficient and flexible decision
making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm …
making. Here we demonstrate a novel, within-subject instrumental lever-pressing paradigm …
Repeated cortico-striatal stimulation generates persistent OCD-like behavior
Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with
obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used …
obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used …
Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients
Autism spectrum disorders (ASDs) are characterized by deficits in social and communication
processes. Recent data suggest that altered functional connectivity (FC), ie synchronous …
processes. Recent data suggest that altered functional connectivity (FC), ie synchronous …
Striatal circuits, habits, and implications for obsessive–compulsive disorder
Highlights•Involvement of corticostriatal circuits in OCD is receiving strong new experimental
support.•This evidence is concordant with clinical evidence based on OCD patient …
support.•This evidence is concordant with clinical evidence based on OCD patient …
Neurobiological model of obsessive–compulsive disorder: Evidence from recent neuropsychological and neuroimaging findings
T Nakao, K Okada, S Kanba - Psychiatry and clinical …, 2014 - Wiley Online Library
Obsessive–compulsive disorder (OCD) was previously considered refractory to most types
of therapeutic intervention. There is now, however, ample evidence that selective serotonin …
of therapeutic intervention. There is now, however, ample evidence that selective serotonin …
Higher media multi-tasking activity is associated with smaller gray-matter density in the anterior cingulate cortex
Media multitasking, or the concurrent consumption of multiple media forms, is increasingly
prevalent in today's society and has been associated with negative psychosocial and …
prevalent in today's society and has been associated with negative psychosocial and …
Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder
Background Obsessive-compulsive disorder (OCD) is associated with regional hyperactivity
in cortico-striatal circuits. However, the large-scale patterns of abnormal neural connectivity …
in cortico-striatal circuits. However, the large-scale patterns of abnormal neural connectivity …