After Edward Jenner established human vaccination over 200 years ago, attenuated
poxviruses became key players to contain the deadliest virus of its own family: Variola virus …

The advantage of oncolytic viruses (OV) in cancer therapy is their dual effect of directly
killing tumours while prompting anti-tumour immune response. Oncolytic parapoxvirus ovis …

Highlights•Oncolytic viruses (OVs) elicit innate and adaptive immune responses against
tumors.•Although the immune system can react against OVs, a functional immune system is …

Natural killer (NK) cell clearance of tumor cell emboli following surgery is thought to be vital
in preventing postoperative metastases. Using a mouse model of surgical stress, we …

Cellular immunotherapy has revolutionized the oncology field, yielding improved results
against hematological and solid malignancies. NK cells have become an attractive …

Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor
vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia …

Background Novel therapies are needed to improve outcomes for women diagnosed with
ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic biologics that …

Oncolytic virotherapy has shown impressive results in preclinical studies and first promising
therapeutic outcomes in clinical trials as well. Since viruses are known for a long time as …

This study characterizes the ability of novel oncolytic rhabdoviruses (Maraba MG1) to boost
natural killer (NK) cell activity. Our results demonstrate that MG1 activates NK cells via direct …

The orf virus (ORFV) is a zoonotic, epitheliotropic, DNA parapoxvirus that infects principally
sheep and goats. Exposure of animals to the virus or immunization by an ORFV preparation …