An update on vitamin D metabolism

F Saponaro, A Saba, R Zucchi - International journal of molecular …, 2020 - mdpi.com
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone
homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been …

Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Non-linear Mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk

A Zhou, JB Selvanayagam… - European heart …, 2022 - academic.oup.com
Aims Low vitamin D status is associated with a higher risk for cardiovascular diseases
(CVDs). Although most existing linear Mendelian randomization (MR) studies reported a null …

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

X Song, X Sun, SF Oh, M Wu, Y Zhang, W Zheng… - Nature, 2020 - nature.com
The metabolic pathways encoded by the human gut microbiome constantly interact with host
gene products through numerous bioactive molecules. Primary bile acids (BAs) are …

Vitamin D and cardiovascular disease, with emphasis on hypertension, atherosclerosis, and heart failure

N Latic, RG Erben - International journal of molecular sciences, 2020 - mdpi.com
Vitamin D deficiency is the most common nutritional deficiency, affecting almost one billion
people worldwide. Vitamin D is mostly known for its role in intestinal calcium absorption and …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Controversies in vitamin D: a statement from the third international conference

A Giustina, R Bouillon, N Binkley… - Journal of Bone and …, 2020 - academic.oup.com
Abstract The Third International Conference on Controversies in Vitamin D was held in
Gubbio, Italy, September 10–13, 2019. The conference was held as a follow up to previous …

Vitamin D and cardiovascular disease: current evidence and future perspectives

N Cosentino, J Campodonico, V Milazzo, M De Metrio… - Nutrients, 2021 - mdpi.com
Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population,
observed across all ethnicities and among all age groups. Besides the established role of …

[HTML][HTML] Vitamin D metabolism, mechanism of action, and clinical applications

DD Bikle - Chemistry & biology, 2014 - cell.com
Vitamin D 3 is made in the skin from 7-dehydrocholesterol under the influence of UV light.
Vitamin D 2 (ergocalciferol) is derived from the plant sterol ergosterol. Vitamin D is …

Role of vitamin D deficiency in the pathogenesis of cardiovascular and cerebrovascular diseases

É Pál, Z Ungvári, Z Benyó, S Várbíró - Nutrients, 2023 - mdpi.com
Deficiency in vitamin D (VitD), a lipid-soluble vitamin and steroid hormone, affects
approximately 24% to 40% of the population of the Western world. In addition to its well …