Taming transposable elements in vertebrates: from epigenetic silencing to domestication
Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …
known to date. Because their expression and mobility can lead to genomic instability …
Lysine acetylation goes global: from epigenetics to metabolism and therapeutics
Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …
Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism
Eukaryotic chromosomes contain compartments of various functions, which are marked by
and enriched with specific histone modifications. However, the molecular mechanisms by …
and enriched with specific histone modifications. However, the molecular mechanisms by …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Silencing and transcriptional regulation of endogenous retroviruses: an overview
FK Geis, SP Goff - Viruses, 2020 - mdpi.com
Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
Abstract Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …
mediates gene silencing,. The chromo domain of HP1 is necessary for both targeting and …
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
M Lachner, D O'Carroll, S Rea, K Mechtler, T Jenuwein - Nature, 2001 - nature.com
Distinct modifications of histone amino termini, such as acetylation, phosphorylation and
methylation, have been proposed to underlie a chromatin-based regulatory mechanism, that …
methylation, have been proposed to underlie a chromatin-based regulatory mechanism, that …
Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET
T Matsui, D Leung, H Miyashita, IA Maksakova… - Nature, 2010 - nature.com
Abstract Endogenous retroviruses (ERVs), retrovirus-like elements with long terminal
repeats, are widely dispersed in the euchromatic compartment in mammalian cells …
repeats, are widely dispersed in the euchromatic compartment in mammalian cells …
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc …
DC Schultz, K Ayyanathan, D Negorev… - Genes & …, 2002 - genesdev.cshlp.org
Posttranslational modification of histones has emerged as a key regulatory signal in
eukaryotic gene expression. Recent genetic and biochemical studies link H3-lysine 9 (H3 …
eukaryotic gene expression. Recent genetic and biochemical studies link H3-lysine 9 (H3 …
Histone methylation in transcriptional control
T Kouzarides - Current opinion in genetics & development, 2002 - Elsevier
Over the past year or so, methylation of histones has come to be recognised as a major
player in the regulation of gene activity. This notion follows the discovery of lysine and …
player in the regulation of gene activity. This notion follows the discovery of lysine and …