Single-cell transcriptomics for the assessment of cardiac disease
AMA Miranda, V Janbandhu, H Maatz… - Nature Reviews …, 2023 - nature.com
Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …
Maturing differentiated human pluripotent stem cells in vitro: methods and challenges
Human pluripotent stem cells (hPSCs), derived from individuals or genetically modified with
disease-related mutations and variants, have revolutionised studies of human disease …
disease-related mutations and variants, have revolutionised studies of human disease …
Integrated multi-omic characterization of congenital heart disease
MC Hill, ZA Kadow, H Long, Y Morikawa, TJ Martin… - Nature, 2022 - nature.com
The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that
when defective results in congenital heart disease (CHD). With current therapies, more than …
when defective results in congenital heart disease (CHD). With current therapies, more than …
Integration mapping of cardiac fibroblast single-cell transcriptomes elucidates cellular principles of fibrosis in diverse pathologies
R Patrick, V Janbandhu, V Tallapragada, SSM Tan… - Science …, 2024 - science.org
Single-cell technology has allowed researchers to probe tissue complexity and dynamics at
unprecedented depth in health and disease. However, the generation of high-dimensionality …
unprecedented depth in health and disease. However, the generation of high-dimensionality …
[HTML][HTML] Vascular cells improve functionality of human cardiac organoids
Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …
cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction …
propeller: testing for differences in cell type proportions in single cell data
Abstract Motivation Single cell RNA-Sequencing (scRNA-seq) has rapidly gained popularity
over the last few years for profiling the transcriptomes of thousands to millions of single cells …
over the last few years for profiling the transcriptomes of thousands to millions of single cells …
Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have wide
potential application in basic research, drug discovery, and regenerative medicine, but …
potential application in basic research, drug discovery, and regenerative medicine, but …
Electrically Conductive Collagen‐PEDOT: PSS Hydrogel Prevents Post‐Infarct Cardiac Arrhythmia and Supports hiPSC‐Cardiomyocyte Function
K Roshanbinfar, M Schiffer, E Carls… - Advanced …, 2024 - Wiley Online Library
Myocardial infarction (MI) causes cell death, disrupts electrical activity, triggers arrhythmia,
and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden …
and results in heart failure, whereby 50–60% of MI‐associated deaths manifest as sudden …
Engineering the maturation of stem cell-derived cardiomyocytes
The maturation of human stem cell-derived cardiomyocytes (hSC-CMs) has been a major
challenge to further expand the scope of their application. Over the past years, several …
challenge to further expand the scope of their application. Over the past years, several …
Sex-dependent transcription of cardiac electrophysiology and links to acetylation modifiers based on the GTEx database
Development of safer drugs based on epigenetic modifiers, eg, histone deacetylase
inhibitors (HDACi), requires better understanding of their effects on cardiac …
inhibitors (HDACi), requires better understanding of their effects on cardiac …