Role of internalin proteins in the pathogenesis of Listeria monocytogenes

K Ireton, R Mortuza, GC Gyanwali… - Molecular …, 2021 - Wiley Online Library
Listeria monocytogenes is a food‐borne bacterium that causes gastroenteritis, meningitis, or
abortion. L. monocytogenes induces its internalization (entry) into human cells and either …

Listeria monocytogenes—How This Pathogen Uses Its Virulence Mechanisms to Infect the Hosts

J Osek, K Wieczorek - Pathogens, 2022 - mdpi.com
Listeriosis is a serious food-borne illness, especially in susceptible populations, including
children, pregnant women, and elderlies. The disease can occur in two forms: non-invasive …

Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts

F Conte, M Oti, J Dixon, CEL Carels, M Rubini, H Zhou - Human genetics, 2016 - Springer
Orofacial clefts (OFCs) represent a large fraction of human birth defects and are one of the
most common phenotypes affected by large copy number variants (CNVs). Due to the limited …

The Diaphanous-Related Formins Promote Protrusion Formation and Cell-to-Cell Spread of Listeria monocytogenes

R Fattouh, H Kwon, MA Czuczman… - The Journal of …, 2015 - academic.oup.com
Abstract The Gram-positive bacterium Listeria monocytogenes is a facultative intracellular
pathogen whose virulence depends on its ability to spread from cell to cell within an infected …

Metabolic adaptation of intracellular bacteria and fungi to macrophages

M Sprenger, L Kasper, M Hensel, B Hube - International Journal of Medical …, 2018 - Elsevier
The mature phagosome of macrophages is a hostile environment for the vast majority of
phagocytosed microbes. In addition to active destruction of the engulfed microbes by …

CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection

KE Yuki, H Marei, E Fiskin, MM Eva, AA Gopal… - Nature …, 2019 - nature.com
Salmonella presents a global public health concern. Central to Salmonella pathogenicity is
an ability to subvert host defences through strategically targeting host proteins implicated in …

Listeria monocytogenes co-opts the host exocyst complex to promote internalin A-mediated entry

GC Gyanwali, TUB Herath, A Gianfelice… - Infection and …, 2022 - Am Soc Microbiol
The bacterial pathogen Listeria monocytogenes induces its internalization (entry) into
intestinal epithelial cells through interaction of its surface protein, internalin A (InlA), with the …

Helicobacter pylori CagA Induces Cortactin Y-470 Phosphorylation-Dependent Gastric Epithelial Cell Scattering via Abl, Vav2 and Rac1 Activation

N Tegtmeyer, A Harrer, K Rottner, S Backert - Cancers, 2021 - mdpi.com
Simple Summary Various microbial pathogens target the actin-binding protein cortactin to
promote their own uptake, proliferation and spread, and exhibit proposed roles in human …

Interaction of microbial pathogens with host exocytic pathways

K Ireton, H Van Ngo, M Bhalla - Cellular Microbiology, 2018 - Wiley Online Library
Many microbial pathogens co‐opt or perturb host membrane trafficking pathways. This
review covers recent examples in which microbes interact with host exocytosis, the fusion of …

Listeria monocytogenes crosses blood brain barrier through Rho GTPases induced migration of macrophages and inflammatory interleukin expression

AD Shahid, Y Lu, MA Iqbal, L Lin, S Huang, X Jiang… - Microbial …, 2021 - Elsevier
Listeria monocytogenes crossing the blood-brain barrier in the form of “Trojan Horse” is of
great significance for the establishment of bacterial encephalitis and meningitis. Induction of …