Loss of E-cadherin-dependent cell–cell adhesion and the development and progression of cancer

HC Bruner, PWB Derksen - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Classical cadherins are the key molecules that control cell–cell adhesion. Notwithstanding
this function, it is also clear that classical cadherins are more than just the “glue” that keeps …

The regulation of the Hippo pathway by intercellular junction proteins

US Ahmad, J Uttagomol, H Wan - Life, 2022 - mdpi.com
The Hippo pathway is an evolutionarily conserved pathway that serves to promote cell death
and differentiation while inhibiting cellular proliferation across species. The downstream …

Overexpression of e-cadherin is a favorable prognostic biomarker in oral squamous cell carcinoma: a systematic review and meta-analysis

AI Lorenzo-Pouso, FFVE Silva, A Perez-Jardon… - Biology, 2023 - mdpi.com
Simple Summary An oral cavity tumor, known as an oral squamous cell carcinoma (OSCC),
has a five-year survival rate of just about 50%. Novel, easily, available biomarkers for …

Oxidative stress-mediated YAP dysregulation contributes to the pathogenesis of pemphigus vulgaris

Y Huang, H Jedličková, Y Cai, A Rehman… - Frontiers in …, 2021 - frontiersin.org
Pemphigus Vulgaris (PV) is a life-threatening autoimmune disease manifested with blisters
in the skin and mucosa and caused by autoantibodies against adhesion protein desmoglein …

Evidence for the desmosomal cadherin desmoglein-3 in regulating YAP and phospho-YAP in keratinocyte responses to mechanical forces

J Uttagomol, US Ahmad, A Rehman, Y Huang… - International journal of …, 2019 - mdpi.com
Desmoglein 3 (Dsg3) plays a crucial role in cell-cell adhesion and tissue integrity.
Increasing evidence suggests that Dsg3 acts as a regulator of cellular mechanotransduction …

Desmoglein‐3 induces YAP phosphorylation and inactivation during collective migration of oral carcinoma cells

US Ahmad, EK Parkinson, H Wan - Molecular Oncology, 2022 - Wiley Online Library
Alterations of the Hippo–YAP pathway are potential targets for oral squamous cell
carcinoma (OSCC) therapy, but heterogeneity in this pathway could be responsible for …

The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53

A Rehman, Y Cai, C Hünefeld, H Jedličková… - Cell Death & …, 2019 - nature.com
Abstract Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an
essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways …

[HTML][HTML] Desmoglein 3–Influence on oral carcinoma cell migration and invasion

EH Apu, SU Akram, J Rissanen, H Wan… - Experimental Cell …, 2018 - Elsevier
Abstract Desmoglein 3 (Dsg3) is an adhesion receptor in desmosomes, but its role in
carcinoma cell migration and invasion is mostly unknown. Our aim was to quantitatively …

Synthetic high-density lipoprotein nanoparticles: Good things in small packages

RM Lavker, N Kaplan, KM McMahon, AE Calvert… - The ocular …, 2021 - Elsevier
Medicine has been a great beneficiary of the nanotechnology revolution. Nanotechnology
involves the synthesis of functional materials with at least one size dimension between 1 …

Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo

NK Bharathan, AJG Dickinson - Developmental biology, 2019 - Elsevier
Desmoplakin (Dsp) is a unique and critical desmosomal protein, that is integral to epidermal
development. However, it is unclear whether this protein is required specifically for …