In the recent past the standard treatment of kala‐azar involved the use of pentavalent
antimonials Sb (V). Because of progressive rise in treatment failure to Sb (V) was limited its …

Post-kala-azar dermal leishmaniasis (PKDL) is a common complication of visceral
leishmaniasis (VL) caused by Leishmania donovani. Because of its possible role in …

Leishmania is the causative agent of various forms of leishmaniasis, a significant cause of
morbidity and mortality. The clinical manifestations of the disease range from self-healing …

The molecular mechanism of antimony-resistant Leishmania donovani (SbRLD)–driven up-
regulation of IL-10 and multidrug-resistant protein 1 (MDR1) in infected macrophages (Mϕs) …

The multifactorial basis of therapeutic response can obscure the relation between
antimicrobial drug susceptibility and clinical outcome. To discern the relationship between …

Leishmania donovani is an intracellular protozoan parasite that causes leishmaniasis, which
can range from a self-healing cutaneous disease to a fatal visceral disease depending on …

Recent clinical isolates of Leishmania donovani from the hyperendemic zone of Bihar were
characterised in vitro in terms of their sensitivity towards sodium stibogluconate in a …

The first-line treatment for Leishmania donovani-induced cutaneous leishmaniasis (CL) in
Sri Lanka is intra-lesional sodium stibogluconate (IL-SSG). Antimony failures in …

HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to
negate their action on target mRNAs. Here we have identified how HuR, by inducing …

Background In an endeavor to find an orally active and affordable antileishmanial drug, we
tested the efficacy of a cationic amphiphilic drug, imipramine, commonly used for the …