Conclusions The CF has recently emerged as one of the most phenotypically plastic cells in
the heart, with distinct transcriptional and secretory programs that regulate their essential …

Diabetes mellitus (DM) is a huge global health issue and one of the most studied diseases,
with a large global prevalence. Oxidative stress is a cytotoxic consequence of the excessive …

Therapeutic targeting of extracellular proteins has attracted huge attention in treating human
diseases. The lysyl oxidases (LOXs) are a family of secreted copper-dependent enzymes …

Fibrosis is an important and essential reparative response to injury that, if left uncontrolled,
results in the excessive synthesis, deposition, remodeling, and stiffening of the extracellular …

Diabetic cardiomyopathy (CM), occurring in the absence of hypertension, coronary artery
disease, and valvular or congenital heart disease, is now recognized as a distinct …

Exercise training is an encouraging approach to treat cardiac dysfunction in type 2 diabetes
(T2DM), but the impact of its intensity is not understood. We aim to investigate whether and …

Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD
pathophysiology is often characterized by increased stiffening of the heart muscle due to …

Chronic alcohol consumption in adults can induce cardiomyopathy, arrhythmias, and heart
failure. In newborns, prenatal alcohol exposure can increase the risk of congenital heart …

Diabetes is a rising global metabolic disorder and leads to long-term consequences. As a
multifactorial disease, the gene-associated mechanisms are important to know. This study …

Background Diabetes mellitus is an independent risk factor for heart failure, and diabetes-
induced heart failure severely affects patients' health and quality of life. Cuproptosis is a …