ContextAlthough postmenopausal hormone replacement therapy (HRT) is widely used in
the United States, new evidence about its benefits and harms requires reconsideration of its …

In this review the usual methods applied in systematic reviews and meta-analyses are
outlined. The ideal hypothesis for a systematic review should be generated by information …

Meta-analysis, decision analysis, and cost-effectiveness analysis are the cornerstones of
evidence-based medicine. These related quantitative methods have become essential tools …

These editors are using the title of the book in an attempt to define a whole new
methodology. Subtitled An Introduction, the book is an integrated collection of 10 chapters …

We sought to determine the strength of the evidence suggesting that estrogen and
postmenopausal replacement hormones play a role in the development of breast cancer …

Editor's note: This and the following two commentaries (pages 779 and 783) are based on
presentations made at the symposium “Meta-analysis of Observational Studies” at the 26th …

The relative effects of postmenopausal hormone replacement therapy (HRT) with estrogen
alone vs. estrogen+ progestin on breast cell proliferation and on breast cancer risk are …

Patients are not alike! This simple truth is often ignored in the analysis of me-cal data, since
most of the time results are presented for the “average” patient. As a result, potential …

Background Recent studies have shown a direct relation between serum estrogen levels
assessed at a single point in time and the risk of breast cancer, but no evidence links …

III. Tamoxifen as an Antitumor Agent A. ER status and the duration of tamoxifen B.
Contralateral breast cancer C. Endometrial cancer D. Conclusions IV. Selective Estrogen …