Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Targeted protein degradation is a novel pharmacology established by drugs that recruit
target proteins to E3 ubiquitin ligases. Based on the structure of the degrader and the target …

Abstract Changes in cellular gene expression in response to small-molecule or genetic
perturbations have yielded signatures that can connect unknown mechanisms of action …

Little is known about the regulation of nonapoptotic cell death. Using massive insertional
mutagenesis of haploid KBM7 cells we identified nine genes involved in small-molecule …

About a thousand genes in the human genome encode for membrane transporters. Among
these, several solute carrier proteins (SLCs), representing the largest group of transporters …

Liver cancers are highly heterogeneous with poor prognosis and drug response. A better
understanding between genetic alterations and drug responses would facilitate precision …

Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and
are major determinants of cellular metabolism. Several SLCs have been shown to be …

Because they mainly do not involve chemical changes, membrane transporters have been a
Cinderella subject in the biotechnology of small molecule production, but this is a serious …

Pancreatic cancer cells undergo intricate metabolic reprogramming to sustain their survival
and proliferation. p53 exhibits a dual role in tumor cell ferroptosis. However, the precise role …