Context: ERBB2 (erb-b2 receptor tyrosine kinase 2 or HER2) is currently the only biomarker
established for selection of a specific therapy for patients with advanced gastroesophageal …

Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which
typically presents in the advanced stages of disease in the majority of patients. Despite the …

The evaluation of biopsied solid organ tissue has long relied on visual examination using a
microscope. Immunohistochemistry is critical in this process, labeling and detecting cell …

The chimeric antigen receptor (CAR) is a genetically engineered receptor that combines a
scFv domain, which specifically recognizes the tumor-specific antigen, with T cell activation …

The HER2 splice variant characterized by the deletion of exon 16 and denominated as
d16HER2, is associated with HER2-positive breast cancer (BC) aggressiveness, stemness …

Aims In the DESTINY-Gastric01 trial, a novel HER2-targeted antibody-drug conjugate
trastuzumab deruxtecan proved to be effective in HER2-low gastro-oesophageal …

Immunohistochemistry (IHC) plays an important role in biomarker-driven cancer therapy.
Although there has been a high demand for standardized and quality assured IHC, it has …

Inhibitors of the programmed cell death 1 (PD-1) signaling axis have recently demonstrated
efficacy and are rapidly being incorporated into the treatment of non–small cell lung cancers …

Context.—Molecular genetics is playing an increasingly important role in patient care and
pathology practice. Immunohistochemistry (IHC) is a valuable and practical tool employed …

Molecular techniques have improved our understanding of the pathogenesis of cancer
development. These techniques have also fueled the rational development of targeted drugs …