Abstract (See the Editorial Commentary by Clancy and Nguyen, on pages 1123–5.)
Background. Invasive candidiasis (IC) is an important healthcare-related infection, with …

The echinocandins are large lipopeptide molecules that are inhibitors of β-(1, 3)-glucan
synthesis, an action that damages fungal cell walls. In vitro and in vivo, the echinocandins …

Abstract The European Conference on Infections in Leukemia (ECIL) provides
recommendations for diagnostic strategies and prophylactic, pre-emptive or targeted therapy …

Clin Microbiol Infect 2012; 18 (Suppl. 7): 19–37 Abstract This part of the EFISG guidelines
focuses on non‐neutropenic adult patients. Only a few of the numerous recommendations …

Candida species are the most common cause of fungal infections. Candida species produce
infections that range from non—life-threatening mucocutaneous illnesses to invasive …

A substantial proportion of patients become colonised with Candida spp during hospital
stay, but only few subsequently develop severe infection. Clinical signs of severe infection …

Background Caspofungin is an echinocandin agent with fungicidal activity against candida
species. We performed a double-blind trial to compare caspofungin with amphotericin B …

Invasive fungal infections are increasingly common in the nosocomial setting. Furthermore,
because risk factors for these infections continue to increase in frequency, it is likely that …

We conducted a prospective, multicenter observational study of adults (n= 1447) and
children (n= 144) with candidemia at tertiary care centers in the United States in parallel with …

Fungi are increasingly recognised as major pathogens in critically ill patients. Candida spp.
and Cryptococcus spp. are the yeasts most frequently isolated in clinical practice. The most …