Nucleic acids are central to the storage and transmission of genetic information. Mechanical
properties, along with their sequence, both enable and fundamentally constrain the …

Magnetic particles are widely used in lab-on-chip and biosensing applications, because
they have a high surface-to-volume ratio, they can be actuated with magnetic fields and …

Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) systems protect bacteria and archaea from infection by viruses and plasmids. Central …

SYBR Gold is a commonly used and particularly bright fluorescent DNA stain, however, its
chemical structure is unknown and its binding mode to DNA remains controversial. Here, we …

There is a wide range of applications for non-covalent DNA binding ligands, and
optimization of such interactions requires detailed understanding of the binding …

DNA stores our genetic information and is ubiquitous in applications, where it interacts with
binding partners ranging from small molecules to large macromolecular complexes. Binding …

Numerous biophysical techniques such as magnetic tweezers, flow stretching assays, or
tethered particle motion assays rely on the tracking of spherical beads to obtain quantitative …

DNA is the carrier of all cellular genetic information and increasingly used in
nanotechnology. Quantitative understanding and optimization of its functions requires …

The nucleus is the organelle in the cell that contains the genome and its associate proteins
which is collectively called chromatin. New work has shown that chromatin and its …

To understand the mechanistic basis of cellular function, immense efforts are undertaken to
investigate the many different molecules that constitute a cell, aiming to probe both …