Mechanically induced signal transduction has an essential role in development. Cells
actively transduce and respond to mechanical signals and their internal architecture must …

The basement membrane (BM) is a special type of extracellular matrix that lines the basal
side of epithelial and endothelial tissues. Functionally, the BM is important for providing …

The keratin network of intermediate filaments provides keratinocytes with essential
mechanical strength and resilience, but the contribution to mechanosensing remains poorly …

Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are
abundant in epithelia and form cytoskeletal networks that contribute to cell type–specific …

Cell migration is a multistep process which relies on the coordination of cytoskeletal
structures in space and time. While the roles of actin and microtubules have been …

Keratin intermediate filament proteins are major cytoskeletal components of the mammalian
simple layered columnar epithelium in the gastrointestinal tract. Human colon crypt epithelial …

Intermediate filaments (IFs) are key players in the control of cell morphology and structure as
well as in active processes such as cell polarization, migration, and mechanoresponses …

Epithelial cells express antimicrobial proteins in response to invading pathogens, although
little is known regarding epithelial defense mechanisms during healthy conditions. Here we …

Cytoplasmic intermediate filaments endow cells with mechanical stability. They are subject
to changes in morphology and composition if needed. This remodeling encompasses entire …

In todays health care, imaging plays an important role throughout the entire clinical process
from diagnostics and treatment planning to surgical procedures and follow up studies. Since …