Clostridioides difficile remains an important public health threat, globally. Since the
emergence of the hypervirulent strain, ribotype 027, new strains have been reported to …

Clostridioides difficile infection (CDI) remains a significant clinical challenge both in the
management of severe and severe-complicated disease and the prevention of recurrence …

Clostridioides difficile infection occurs when the bacterium produces toxin that causes
diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to …

Metronidazole was until recently used as a first-line treatment for potentially life-threatening
Clostridioides difficile (CD) infection. Although cases of metronidazole resistance have been …

Objective To systematically assess the current related methodological quality of guidelines
for the diagnosis and treatment of Clostridioides difficile infection (CDI), revealing the …

Clostridioides difficile is the most important cause of healthcare-associated diarrhea in the
United States. The high incidence and recurrence rates of C. difficile infection (CDI) …

With current first-in-line antibiotic therapy options associated with high levels of recurrent
CDI, the availability of new generation targeted therapeutics can really impact treatment …

Methods This retrospective, multicenter study was conducted by 83 investigators who were
members of the Asian Organization for Crohn's and Colitis. Data on opportunistic infection …

Dysbiosis of the gut microbiota, caused by antibiotics, plays a key role in the establishment
of Clostridioides difficile CD). Toxin-producing strains are involved in the pathogenesis of …

Background Antibiotic use is associated with several antibiotic-related harms in vulnerable,
older long-term care (LTC) residents. Suboptimal antibiotic use may also be associated with …