The mechanistic target of rapamycin complex 1 (mTORC1) is indispensable for preserving
cellular and organismal homeostasis by balancing the anabolic and catabolic processes in …

Macroautophagy/autophagy is a conserved lysosomal degradation process composed of
both selective and nonselective degradation pathways. The latter occurs upon nutrient …

Tuberous sclerosis complex (TSC) is a multi-organ genetic disorder. TSC occurs in about 1
in 6,000 births. TSC is caused by mutations in either TSC1 or TSC2 which encode hamartin …