Synthetic extracellular matrices with function-encoding peptides
The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …
A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery
Microsurgical techniques for the treatment of large peripheral nerve injuries (such as the
gold standard autograft) and its main clinically approved alternative—hollow nerve guidance …
gold standard autograft) and its main clinically approved alternative—hollow nerve guidance …
[HTML][HTML] Advances in the diagnosis and treatment of dry eye
T Kojima, M Dogru, M Kawashima, S Nakamura… - Progress in retinal and …, 2020 - Elsevier
The core mechanism of dry eye is the tear film instability. Tear film-oriented diagnosis
(TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film …
(TFOD) is a concept to clarify the cause of tear film instability by tear film, and tear film …
Innovative therapy for Alzheimer's disease-with focus on biodelivery of NGF
S Mitra, H Behbahani, M Eriksdotter - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …
Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-
related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several …
related kinase B (TrkB) have emerged as key mediators in the pathophysiology of several …
Antagonism of nerve growth factor-TrkA signaling and the relief of pain
Nerve growth factor (NGF) was originally discovered as a neurotrophic factor essential for
the survival of sensory and sympathetic neurons during development. However in the adult …
the survival of sensory and sympathetic neurons during development. However in the adult …
Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease
FM Longo, SM Massa - Nature reviews Drug discovery, 2013 - nature.com
Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …
Neuropathic corneal pain: approaches for management
G Dieckmann, S Goyal, P Hamrah - Ophthalmology, 2017 - Elsevier
Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and
can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined …
can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined …
[HTML][HTML] Astrogliosis as a therapeutic target for neurodegenerative diseases
Chronic neurodegenerative diseases represent major unmet needs for therapeutic
interventions. Recently, the neurocentric view of brain function and disease has been …
interventions. Recently, the neurocentric view of brain function and disease has been …
Autologous serum tears for treatment of photoallodynia in patients with corneal neuropathy: efficacy and evaluation with in vivo confocal microscopy
S Aggarwal, A Kheirkhah, BM Cavalcanti, A Cruzat… - The ocular …, 2015 - Elsevier
Objective Patients suffering from corneal neuropathy may present with photoallodynia; ie,
increased light sensitivity, frequently with a normal slit-lamp examination. This study aimed …
increased light sensitivity, frequently with a normal slit-lamp examination. This study aimed …