Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of extranodal non-
Hodgkin's lymphomas that are characterized by a cutaneous infiltration of malignant …

Patients with angioimmunoblastic T-cell lymphoma (AITL) and other peripheral T-cell
lymphomas that harbor features of follicular helper T (TFH) cells have a very poor prognosis …

Everolimus is a kind of mammalian target of rapamycin (mTOR) inhibitors. Activated mitogen-
activated protein kinase interacting kinases/eukaryotic translation initiation factor 4E …

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy with a poor
prognosis with current therapy. Here we report genome-wide CRISPR-Cas9 screening of …

Simple Summary In the last few years, the field of cutaneous T-cell lymphomas has
experienced major advances. In the context of an active translational and clinical research …

The RASopathies are a group of clinically defined developmental syndromes caused by
germline variants of the RAS/mitogen‐activated protein (MAPK) cascade. The prototypic …

Although the value of proteomics has been demonstrated, cost and scale are typically
prohibitive, and gene expression profiling remains dominant for characterizing cellular …

Purpose: Peripheral T-cell lymphomas are clinically aggressive and usually fatal, as few
complete or durable remissions are achieved with currently available therapies. Recent …