Disorders resulting from 5p deletions (5p−) were first recognized by Lejeune et al. in 1963
[Lejeune et al.(1963); CR Hebd Seances Acad Sci 257: 3098–3102]. 5p− is caused by …

In the arteries of vertebrates, evolution has given rise to resilient macromolecular structures,
elastin and elastic fibers, capable of sustaining an elevated blood pressure and …

ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame‐shift
mutation in colorectal cancer (CRC). However, its expression and biological function were …

Recent advances in induced pluripotent stem cell (iPSC) technology and directed
differentiation of iPSCs into cardiomyocytes (iPSC-CMs) make it possible to model genetic …

Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial
infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve …

The ten-eleven translocation family of proteins (Tet1/2/3, Tets) converts 5-methylcytosine
(5mC) to 5-hydroxymethylcytosine (5hmC), which can be further oxidized and repaired by …

Tissue-engineered small-diameter vascular grafts have been developed as a promising
alternative to native veins or arteries for replacement therapy. However, there is still a crucial …

Abstract N6-methyladenosine (m6A) is the most prevalent modification of RNA in mammals.
m6A RNA methylation levels are dynamically regulated by m6A RNA methylation regulators …

Elastic Fiber Matrices: Biomimetic Approaches to Regeneration and Repair provides a
comprehensive resource on the intrinsic and pathological aberrations of the complex …

This invention relates to the forward programming of pluripotent stem cells (PSCs) into
megakaryocyte (MK) progenitor cells using the transcription factors GATA1, FLI1 and TAL1 …