Among the four proteolytic systems in the cell, autophagy and the ubiquitin-proteasome
system (UPS) are the main proteolytic events that allow for the removal of cell debris and …

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease, and its prevalence
has grown worldwide. Several pathophysiological processes contribute to the development …

MicroRNAs (miRNAs) regulate molecular processes governing muscle metabolism. Physical
activity and energy balance influence both muscle anabolism and substrate metabolism, but …

miR-486 is a muscle-enriched microRNA, or “myomiR,” that has reduced expression
correlated with Duchenne muscular dystrophy (DMD). To determine the function of miR-486 …

Background Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS).
However, the mechanism underlying enhanced Th17 cell accumulation in AS remains …

In a previous study, the whole transcriptome of the vastus lateralis muscle from sedentary
elderly and from age-matched athletes with an exceptional record of high-intensity, life-long …

Objective We aimed to investigate the therapeutic effects of Moringa oleifera leaf extracts on
osteogenic induction of rat bone marrow mesenchymal stem cells (BMSCs) following …

MicroRNAs (miRNAs) play an essential role in many biological processes. In this study,
miRNAs in the skeletal muscle of normal and intrauterine growth retardation (IUGR) …

Insulin signaling plays a key role in glucose uptake, glycogen synthesis, and protein and
lipid synthesis. In insulin-resistant states like obesity and type 2 diabetes mellitus, these …

Posttranscriptional regulation by microRNA (miRNA) facilitates exercise and diet-induced
skeletal muscle adaptations. However, the impact of diet on miRNA expression during …