Peptide-and aptamer-functionalized nanovectors for targeted delivery of therapeutics

TO Pangburn, MA Petersen, B Waybrant, MM Adil… - 2009 - asmedigitalcollection.asme.org
Targeted delivery of therapeutics is an area of vigorous research, and peptide-and aptamer-
functionalized nanovectors are a promising class of targeted delivery vehicles. Both peptide …

The features and shortcomings for gene delivery of current non-viral carriers

K Kodama, Y Katayama, Y Shoji… - Current Medicinal …, 2006 - ingentaconnect.com
Since the viral vector for gene therapy has serious problems, including oncogenesity and
other adverse effects, non-viral carriers have attracted a great deal of attention. Non-viral …

[图书][B] Chitin and chitosan derivatives: advances in drug discovery and developments

SK Kim - 2013 - books.google.com
A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the
exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and …

The gene transfection efficiency of thermoresponsive N, N, N-trimethyl chitosan chloride-g-poly (N-isopropylacrylamide) copolymer

Z Mao, L Ma, J Yan, M Yan, C Gao, J Shen - Biomaterials, 2007 - Elsevier
A thermoresponsive copolymer, trimethyl chitosan-g-poly (N-isopropylacrylamide)(TMC-g-
PNIPAAm), was synthesized by coupling PNIPAAm-COOH to TMC. Their molecular …

Thiolated trimethyl chitosan nanocomplexes as gene carriers with high in vitro and in vivo transfection efficiency

X Zhao, L Yin, J Ding, C Tang, S Gu, C Yin… - Journal of Controlled …, 2010 - Elsevier
Trimethyl chitosan–cysteine conjugate (TMC–Cys) was evaluated as non-viral gene carriers
to combine the advantages of TMC and thiolated chitosan. TMC–Cys with various molecular …

Biological stimuli and biomolecules in the assembly and manipulation of nanoscale polymeric particles

LM Randolph, MP Chien, NC Gianneschi - Chemical Science, 2012 - pubs.rsc.org
Living systems are replete with complex, stimuli-responsive nanoscale materials and
molecular self-assemblies. There is an ever increasing and intense interest within the …

Design of polymeric carriers for cancer-specific gene targeting: utilization of abnormal protein kinase Cα activation in cancer cells

JH Kang, D Asai, JH Kim, T Mori, R Toita… - Journal of the …, 2008 - ACS Publications
Design of Polymeric Carriers for Cancer-Specific Gene Targeting: Utilization of Abnormal
Protein Kinase Cα Activation in Cancer Cells | Journal of the American Chemical Society ACS …

A thermoresponsive chitosan− NIPAAm/vinyl laurate copolymer vector for gene transfection

S Sun, W Liu, N Cheng, B Zhang, Z Cao… - Bioconjugate …, 2005 - ACS Publications
A carboxyl-terminated N-isopropylacrylamide/vinyl laurate (VL) copolymer was prepared
and coupled with chitosan (molecular weight= 2000) to produce a chitosan− NIPAAm/VL …

Phosphorylation of Rho-associated kinase (Rho-kinase/ROCK/ROK) substrates by protein kinases A and C

JH Kang, Y Jiang, R Toita, J Oishi, K Kawamura, A Han… - Biochimie, 2007 - Elsevier
Rho-associated kinase (Rho-kinase/ROCK/ROK) is a serine/threonine kinase and plays an
important role in various cellular functions. The cAMP-dependent protein kinase (protein …

The concept of molecular machinery is useful for design of stimuli-responsive gene delivery systems in the mammalian cell

T Nagasaki, S Shinkai - Journal of Inclusion Phenomena and Macrocyclic …, 2007 - Springer
Since the first generation of molecular machines including photoresponsive crown ethers
and its analogues was reported by Shinkai et al., a huge number of molecular machines …