Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Vascular endothelial cells (ECs) senescence correlates with the increase of cardiovascular
diseases in ageing population. Although ECs rely on glycolysis for energy production, little is …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Hypertension is one of the leading causes of chronic kidney disease characterized with
renal fibrosis. This study aimed to investigate roles and mechanisms of sirtuin 7 (SIRT7) in …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

Aims The mechanisms underlying ageing-induced vascular remodelling remain unclear.
This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase …

The FOXM1 transcription factor exhibits pleiotropic C-terminal transcriptional and N-terminal
non-transcriptional functions in various biological processes critical for cellular homeostasis …

Abstract Aims Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing
syndrome associated with premature vascular disease and death due to heart attack and …