Seasonal and Species Variation of the Hepatotoxin Indospicine in Australian Indigofera Legumes As Measured by UPLC-MS/MS

ETT Tan, CM Materne, RG Silcock… - Journal of agricultural …, 2016 - ACS Publications
Livestock industries have maintained a keen interest in pasture legumes because of the
high protein content and nutritive value. Leguminous Indigofera plant species have been …

Accumulation, Persistence, and Effects of Indospicine Residues in Camels Fed Indigofera Plant

ETT Tan, R Al Jassim, AJ Cawdell-Smith… - Journal of agricultural …, 2016 - ACS Publications
Indospicine (l-2-amino-6-amidinohexanoic acid) is a natural hepatotoxin found in all parts of
some Indigofera plants such as Indigofera linnaei and Indigofera spicata. Several studies …

A real-time PCR method targeting camel ingredient for food authentication

Y Wu, Y Yang, B Wang, M Liu, J Han… - Journal of AOAC …, 2015 - academic.oup.com
The special nutritious value of camel showed high potential for market exploitation. In this
paper, a real-time PCR method targeting camel ingredient in camel meat and milk is …

Synthesis of l-indospicine,[5, 5, 6-2 H 3]-l-indospicine and l-norindospicine

CS Lang, SH Wong, S Chow, VL Challinor… - Organic & …, 2016 - pubs.rsc.org
Indospicine is a non-proteogenic amino acid that accumulates as the free amino acid in
livestock grazing Indigofera plant species and causes both reproductive losses and …

Thermo-alkaline treatment as a practical degradation strategy to reduce indospicine contamination in camel meat

ETT Tan, KWL Yong, SH Wong, BR D'Arcy… - Journal of agricultural …, 2016 - ACS Publications
Ingestion of indospicine-contaminated camel and horse meat has caused fatal liver injury to
dogs in Australia, and it is currently not known if such contaminated meat may pose a human …

In Vitro Biodegradation of Hepatotoxic Indospicine in Indigofera spicata and Its Degradation Derivatives by Camel Foregut and Cattle Rumen Fluids

ETT Tan, R Al Jassim, BR D'Arcy… - Journal of agricultural …, 2017 - ACS Publications
The known accumulation of the hepatotoxin indospicine in tissues of camels and cattle
grazing Indigofera pasture plants is unusual in that free amino acids would normally be …

Emerging food safety risk of hepatotoxic indospicine in feral Australian camel meat

ETT Tan, JC Ng, R Al Jassim, BR D'Arcy, G Netzel… - Food Control, 2020 - Elsevier
Indospicine is a hepatotoxic non-proteinogenic amino acid that has only been found in
Indigofera plants including a number of species abundant in central Australia. These …

Bioaccumulation and Distribution of Indospicine and Its Foregut Metabolites in Camels Fed Indigofera spicata

G Netzel, ETT Tan, M Yin, C Giles, KWL Yong… - Toxins, 2019 - mdpi.com
In vitro experiments have demonstrated that camel foregut-fluid has the capacity to
metabolize indospicine, a natural toxin which causes hepatotoxicosis, but such metabolism …

Investigation of different enzyme markers in some pathological disorders of the dromedary camels in comparison with other species.

H Abu Damir, MA Ali, AE Khalafalla - CABI Reviews, 2018 - cabidigitallibrary.org
Camel adaptation to its arid and semi-arid environment and its genetic make-up created
some differences in its enzyme systems compared with other domestic animals. The camel …

Release of indospicine from contaminated camel meat following cooking and simulated gastrointestinal digestion: Implications for human consumption

S Sultan, C Giles, G Netzel, SA Osborne, ME Netzel… - Toxins, 2018 - mdpi.com
Indospicine, a hepatotoxic arginine analog, occurs in leguminous plants of the Indigofera
genus and accumulates in the tissues of grazing animals that consume these plants …