Triggering and resolution of inflammation in NASH

S Schuster, D Cabrera, M Arrese… - Nature reviews …, 2018 - nature.com
Nonalcoholic steatohepatitis (NASH) is considered the progressive form of nonalcoholic fatty
liver disease (NAFLD) and is characterized by liver steatosis, inflammation, hepatocellular …

Molecular pathogenesis of NASH

A Caligiuri, A Gentilini, F Marra - International journal of molecular …, 2016 - mdpi.com
Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the
Western world and a major health problem, owing to its close association with obesity …

Pathogenesis of NASH: the impact of multiple pathways

M Noureddin, AJ Sanyal - Current hepatology reports, 2018 - Springer
Purpose of review Advancing our understanding of the mechanisms that underlie NASH
pathogenesis. Recent findings Recent findings on NASH pathogenesis have expanded our …

Downregulation of hepatic ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex

L Xie, Y Yuan, S Xu, S Lu, J Gu, Y Wang, Y Wang… - Cell reports, 2022 - cell.com
Copper deficiency has emerged to be associated with various lipid metabolism diseases,
including non-alcoholic fatty liver disease (NAFLD). However, the mechanisms that dictate …

Copper deficiency may be a leading cause of ischaemic heart disease

JJ DiNicolantonio, D Mangan, JH O'Keefe - Open heart, 2018 - openheart.bmj.com
Biological properties of copper Copper is involved in the functions of many copper-
dependent proteins, including transcriptional regulators, chaperones, oxidoreductases …

The role of insufficient copper in lipid synthesis and fatty‐liver disease

A Morrell, S Tallino, L Yu, JL Burkhead - IUBMB life, 2017 - Wiley Online Library
The essential transition metal copper is important in lipid metabolism, redox balance, iron
mobilization, and many other critical processes in eukaryotic organisms. Genetic diseases …

The vital role of ATP citrate lyase in chronic diseases

AD Khwairakpam, K Banik, S Girisa… - Journal of Molecular …, 2020 - Springer
Chronic or non-communicable diseases are the leading cause of death worldwide; they
usually result in long-term illnesses and demand long-term care. Despite advances in …

Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

C Ma, L Han, Z Zhu, CH Pang, G Pan - Biochemical Pharmacology, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver
disease worldwide. Minerals including iron, copper, zinc, and selenium, fulfil an essential …

Non-alcoholic fatty liver disease and nutritional implications: special focus on copper

L Antonucci, C Porcu, G Iannucci, C Balsano… - Nutrients, 2017 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipids in hepatocytes,
due to excessive fatty acid influx from adipose tissue, de novo hepatic lipogenesis, in …

Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes

H Yang, M Ralle, MJ Wolfgang, N Dhawan… - PLoS …, 2018 - journals.plos.org
Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how
Cu contributes to the physiology of fat cells remains largely unknown. We found that …