Retinal neurodegenerative diseases like age-related macular degeneration, glaucoma,
diabetic retinopathy and retinitis pigmentosa each have a different etiology and …

Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural
degenerative disease usually caused by gene defects that disrupt the function or …

Photoreceptor replacement by transplantation is proposed as a treatment for blindness.
Transplantation of healthy photoreceptor precursor cells into diseased murine eyes leads to …

In this article, we show that mouse embryonic stem cell-or induced pluripotent stem cell-
derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete …

Retinal neurodegeneration associated with the dysfunction or death of photoreceptors is a
major cause of incurable vision loss. Tremendous progress has been made over the last two …

The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

INTRODUCTION Regenerative therapies based on cell replacement hold promise for the
treatment of a range of age-related degenerative diseases but are limited by unfavorable …

The utility of stem cells and their progeny in adult transplantation models has been limited by
poor survival and integration. We designed an injectable and bioresorbable hydrogel blend …

Late-stage retinal degenerative disease involving photoreceptor loss can be treated by
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …

One strategy to restore vision in retinitis pigmentosa and age-related macular degeneration
is cell replacement. Typically, patients lose vision when the outer retinal photoreceptor layer …