Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
Inflammation and DNA damage: cause, effect or both
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …
R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response
Abstract R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …
PARP1 associates with R-loops to promote their resolution and genome stability
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …
[PDF][PDF] Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy
B Viengkhou, C Hong, C Mazur… - Journal of Clinical …, 2024 - Am Soc Clin Investig
Chronic and elevated levels of the antiviral cytokine IFN-α in the brain are neurotoxic. This is
best observed in patients with genetic cerebral interferonopathies such as Aicardi-Goutières …
best observed in patients with genetic cerebral interferonopathies such as Aicardi-Goutières …
Inborn errors of immunity: an expanding universe of disease and genetic architecture
YT Akalu, D Bogunovic - Nature Reviews Genetics, 2024 - nature.com
Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of
the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy …
the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy …
A novel STING variant triggers endothelial toxicity and SAVI disease
E Valeri, S Breggion, F Barzaghi… - Journal of Experimental …, 2024 - rupress.org
Gain-of-function mutations in STING cause STING-associated vasculopathy with onset in
infancy (SAVI) characterized by early-onset systemic inflammation, skin vasculopathy, and …
infancy (SAVI) characterized by early-onset systemic inflammation, skin vasculopathy, and …
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner
T Schumann, SC Ramon, N Schubert… - Journal of Experimental …, 2022 - rupress.org
Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …
Updated roles of cGAS-STING signaling in autoimmune diseases
Y Liu, F Pu - Frontiers in Immunology, 2023 - frontiersin.org
Natural immunity, the first line for the body to defense against the invasion of pathogen,
serves as the body's perception of the presence of pathogens depends on nucleic acid …
serves as the body's perception of the presence of pathogens depends on nucleic acid …