Walking a tightrope: the complex balancing act of R-loops in genome stability

JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

Inflammation and DNA damage: cause, effect or both

A Pezone, F Olivieri, MV Napoli, A Procopio… - Nature Reviews …, 2023 - nature.com
Inflammation is a biological response involving immune cells, blood vessels and mediators
induced by endogenous and exogenous stimuli, such as pathogens, damaged cells or …

R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response

MP Crossley, C Song, MJ Bocek, JH Choi… - Nature, 2023 - nature.com
Abstract R-loops are RNA–DNA-hybrid-containing nucleic acids with important cellular
roles. Deregulation of R-loop dynamics can lead to DNA damage and genome instability …

PARP1 associates with R-loops to promote their resolution and genome stability

N Laspata, P Kaur, SY Mersaoui, D Muoio… - Nucleic acids …, 2023 - academic.oup.com
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19

J Radke, J Meinhardt, T Aschman, RL Chua… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …

[PDF][PDF] Interferon-α receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy

B Viengkhou, C Hong, C Mazur… - Journal of Clinical …, 2024 - Am Soc Clin Investig
Chronic and elevated levels of the antiviral cytokine IFN-α in the brain are neurotoxic. This is
best observed in patients with genetic cerebral interferonopathies such as Aicardi-Goutières …

Inborn errors of immunity: an expanding universe of disease and genetic architecture

YT Akalu, D Bogunovic - Nature Reviews Genetics, 2024 - nature.com
Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of
the immune system that cause immunodeficiency, autoinflammation, autoimmunity, allergy …

A novel STING variant triggers endothelial toxicity and SAVI disease

E Valeri, S Breggion, F Barzaghi… - Journal of Experimental …, 2024 - rupress.org
Gain-of-function mutations in STING cause STING-associated vasculopathy with onset in
infancy (SAVI) characterized by early-onset systemic inflammation, skin vasculopathy, and …

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner

T Schumann, SC Ramon, N Schubert… - Journal of Experimental …, 2022 - rupress.org
Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …

Updated roles of cGAS-STING signaling in autoimmune diseases

Y Liu, F Pu - Frontiers in Immunology, 2023 - frontiersin.org
Natural immunity, the first line for the body to defense against the invasion of pathogen,
serves as the body's perception of the presence of pathogens depends on nucleic acid …