Macrophages in tissue repair, regeneration, and fibrosis
TA Wynn, KM Vannella - Immunity, 2016 - cell.com
Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …
Molecular and cellular insights into T cell exhaustion
EJ Wherry, M Kurachi - Nature reviews immunology, 2015 - nature.com
In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …
inflammatory signals. This scenario is often associated with the deterioration of T cell …
Antibody–Fc/FcR interaction on macrophages as a mechanism for hyperprogressive disease in non–small cell lung cancer subsequent to PD-1/PD-L1 blockade
Abstract Purpose: Hyperprogression (HP), a paradoxical boost in tumor growth, was
described in a subset of patients treated with immune checkpoint inhibitors (ICI). Neither …
described in a subset of patients treated with immune checkpoint inhibitors (ICI). Neither …
CD8 T cell exhaustion during chronic viral infection and cancer
LM McLane, MS Abdel-Hakeem… - Annual review of …, 2019 - annualreviews.org
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
Mechanisms of organ injury and repair by macrophages
KM Vannella, TA Wynn - Annual review of physiology, 2017 - annualreviews.org
Macrophages regulate tissue regeneration following injury. They can worsen tissue injury by
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …
producing reactive oxygen species and other toxic mediators that disrupt cell metabolism …
Immunological landscape and immunotherapy of hepatocellular carcinoma
J Prieto, I Melero, B Sangro - Nature reviews Gastroenterology & …, 2015 - nature.com
Advanced hepatocellular carcinoma (HCC) is a serious therapeutic challenge and targeted
therapies only provide a modest benefit in terms of overall survival. Novel approaches are …
therapies only provide a modest benefit in terms of overall survival. Novel approaches are …
IL‐10: a multifunctional cytokine in viral infections
JM Rojas, M Avia, V Martín… - Journal of immunology …, 2017 - Wiley Online Library
The anti‐inflammatory master regulator IL‐10 is critical to protect the host from tissue
damage during acute phases of immune responses. This regulatory mechanism, central to T …
damage during acute phases of immune responses. This regulatory mechanism, central to T …
Clinical blockade of PD1 and LAG3—potential mechanisms of action
LT Nguyen, PS Ohashi - Nature Reviews Immunology, 2015 - nature.com
Dysfunctional T cells can render the immune system unable to eliminate infections and
cancer. Therapeutic targeting of the surface receptors that inhibit T cell function has begun to …
cancer. Therapeutic targeting of the surface receptors that inhibit T cell function has begun to …
T cell exhaustion
EJ Wherry - Nature immunology, 2011 - nature.com
T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections
and cancer. It is defined by poor effector function, sustained expression of inhibitory …
and cancer. It is defined by poor effector function, sustained expression of inhibitory …
Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
MB Bernstein, S Krishnan, JW Hodge… - Nature reviews Clinical …, 2016 - nature.com
Conventional radiotherapy, in addition to its well-established tumoricidal effects, can also
activate the host immune system. Radiation therapy modulates tumour phenotypes …
activate the host immune system. Radiation therapy modulates tumour phenotypes …