Conceptual simplicity, the possibility of rational design, relatively inexpensive cost, and
developments in the sequencing of human genome have led to the use of short fragments of …

The astonishing discovery that peptide nucleic acids (PNAs, B= nucleobase), in spite of their
drastic structural difference to natural DNA, are better nucleic acid mimetics than many other …

Since the elucidation of the double helical structure of DNA (deoxyribonucleic acid), our
genetic material, the properties of this remarkable molecule have fascinated chemists, and …

Peptide nucleic acid (PNA) is a DNA mimic having a pseudopeptide backbone that makes it
extremely stable in biological fluids. PNA binds complementary RNA and DNA with high …

The BCR/ABL fusion protein transforms myeloid stem cells. Both chronic myelogenous
leukemias (CML) and a subset of acute lymphoblastic leukemias (ALL) are associated with …

Specific gene expression involves the binding of natural ligands to the DNA base pairs.
Among the compounds rationally designed for artificial regulation of gene expression …

Iron is essential for survival and proliferation of Ehrlichia chaffeensis, an obligatory
intracellular bacterium that causes an emerging zoonosis, human monocytic ehrlichiosis …

Since their invention in 1991, peptide nucleic acids (PNAs) have been used in a myriad of
chemical and biological assays. More recently, peptide nucleic acids have also been …

Peptide nucleic acid (PNA) oligomers were conjugated to cell-penetrating peptides: pAnt, a
17-residue fragment of the Drosophila protein Antennapedia, and pTat, a 14-amino acid …

Sequence-specificity is the key to effective genetic targeting. With specificity, targeted genes
can be manipulated in multiple ways; without it, gene therapy agents become loose canons …