Despite improvements in medical therapy and device‐based treatment, heart failure (HF)
continues to impose enormous burdens on patients and health care systems worldwide …

Left ventricular hypertrophy (LVH) is the most common myocardial structural abnormality
associated with heart failure with preserved ejection fraction (HFpEF). LVH is driven by …

212 Circulation Research July 7, 2014 and others19, 20 confirmed and re-enforced these
observations. Furthermore, Osborn et al21 demonstrated that low-frequency stimulation of …

Aims Sympathetic stimulation induces left ventricular hypertrophy and is associated with
increased cardiovascular risk. Catheter-based renal denervation (RDN) has been shown to …

Background: Arterial hypertension is the most common comorbidity in patients with heart
failure with preserved ejection fraction (HFpEF) and mediates adverse hemodynamics …

Cardiorenal syndromes (CRS) describe concomitant bidirectional dysfunction of the heart
and kidneys in which 1 organ initiates, perpetuates, and/or accelerates decline of the other …

Objectives To investigate, whether renal denervation (RDN) has a direct effect on cardiac
sympathetic activity and innervation density. Background RDN demonstrated its efficacy not …

Background Recent trial results support the efficacy of renal sympathetic denervation in
lowering blood pressure (BP). While BP reduction in general is associated with a clinically …

Hypertension imposes a major burden of morbidity and mortality and is associated with
sympathetic nervous system overactivity. Renal sympathetic denervation has been shown to …

Whereas hypertension, diabetes, and dyslipidemia are age-related risk factors for
cardiovascular disease (CVD) and chronic kidney disease (CKD), aging alone is an …