The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically
relevant tumor-targeting immune responses, which critically rely on the antigenicity of …

The clinical manifestation of neurodegenerative diseases is initiated by the selective
alteration in the functionality of distinct neuronal populations. The pathology of many …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized
secretory cells and is also involved in the pathogenesis of many human diseases. ER stress …

Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular
functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful …

The unfolded protein response (UPR) is a homeostatic mechanism by which cells regulate
levels of misfolded proteins in the endoplasmic reticulum (ER). Although it is well …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
synaptic dysfunction and accumulation of abnormal aggregates formed by amyloid‐β …