Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates
centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and …

For more than 15 years, TPX2 has been studied as a factor critical for mitosis and spindle
assembly. These functions of TPX2 are attributed to its Ran-regulated microtubule …

Many protein kinases are activated by a conserved regulatory step involving T-loop
phosphorylation. Although there is considerable focus on kinase activator proteins, the …

The Aurora-A kinase regulates cell division by phosphorylating multiple downstream targets
in the mitotic apparatus. Aurora-A is frequently overexpressed in tumor cells and it is …

Aurora kinase A (AURKA) performs critical functions in mitosis. Thus, the activity and
subcellular localization of AURKA are tightly regulated and depend on diverse factors …

Recurrent ovarian cancer is resistant to conventional chemotherapy. A sub-population of
ovarian cancer cells, the epithelial ovarian cancer stem cells (EOC stem cells) have …

Mutations in the PPP6C catalytic subunit of protein phosphatase 6 (PP6) are drivers for the
development of melanoma. Here, we analyse a panel of melanoma-associated mutations in …

Abstract Purpose: Despite more than 70,000 new cases of bladder cancer in the United
States annually, patients with advanced disease have a poor prognosis due to limited …

The Aurora-A kinase has well-established roles in spindle assembly and function and is
frequently overexpressed in tumours. Its abundance is cell cycle regulated, with a peak in …