Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
The prevalence of heart failure is on the rise and imposes a major health threat, in part, due
to the rapidly increased prevalence of overweight and obesity. To this point …
to the rapidly increased prevalence of overweight and obesity. To this point …
Obesity: global epidemiology and pathogenesis
M Blüher - Nature Reviews Endocrinology, 2019 - nature.com
The prevalence of obesity has increased worldwide in the past~ 50 years, reaching
pandemic levels. Obesity represents a major health challenge because it substantially …
pandemic levels. Obesity represents a major health challenge because it substantially …
[HTML][HTML] Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution
AK Sárvári, EL Van Hauwaert, LK Markussen… - Cell metabolism, 2021 - cell.com
Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …
The science of obesity management: an endocrine society scientific statement
GA Bray, WE Heisel, A Afshin, MD Jensen… - Endocrine …, 2018 - academic.oup.com
The prevalence of obesity, measured by body mass index, has risen to unacceptable levels
in both men and women in the United States and worldwide with resultant hazardous health …
in both men and women in the United States and worldwide with resultant hazardous health …
Ten principles of heterochromatin formation and function
RC Allshire, HD Madhani - Nature reviews Molecular cell biology, 2018 - nature.com
Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …
particular genomic domains with specific functional properties. The capacity of …
Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …
of genes, is required for normal development, and its disruption leads to human disease …
Obesity in low-and middle-income countries: burden, drivers, and emerging challenges
We have reviewed the distinctive features of excess weight, its causes, and related
prevention and management efforts, as well as data gaps and recommendations for future …
prevention and management efforts, as well as data gaps and recommendations for future …
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Ovarian hormones and obesity
BACKGROUND Obesity is caused by an imbalance between energy intake, ie eating and
energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide …
energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide …
On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations
A Qasim, M Turcotte, RJ de Souza… - Obesity …, 2018 - Wiley Online Library
Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …
detrimental impact on human health persist through evolutionary time? Numerous …