The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age‐related ocular diseases and other pathologies of the anterior and …

M Nita, A Grzybowski - Oxidative medicine and cellular …, 2016 - Wiley Online Library
The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …

[HTML][HTML] The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target

DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …

[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial

DS Liao, FV Grossi, D El Mehdi, MR Gerber, DM Brown… - Ophthalmology, 2020 - Elsevier
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …

Injectable anti‐inflammatory supramolecular nanofiber hydrogel to promote anti‐VEGF therapy in age‐related macular degeneration treatment

H Gao, M Chen, Y Liu, D Zhang, J Shen… - Advanced …, 2023 - Wiley Online Library
Age‐related macular degeneration (AMD) is a major cause of visual impairment and severe
vision loss worldwide, while the currently available treatments are often unsatisfactory …

Retinal microglia: just bystander or target for therapy?

M Karlstetter, R Scholz, M Rutar, WT Wong… - Progress in retinal and …, 2015 - Elsevier
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

[HTML][HTML] Neovascular age-related macular degeneration: therapeutic management and new-upcoming approaches

F Ricci, F Bandello, P Navarra, G Staurenghi… - International journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive
retinal degenerative disease of the macula that affects elderly people and cause central …

[HTML][HTML] Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies

CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …

[HTML][HTML] Mechanisms of age-related macular degeneration

J Ambati, BJ Fowler - Neuron, 2012 - cell.com
Age-related macular degeneration (AMD), a progressive condition that is untreatable in up
to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of …

[HTML][HTML] Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris …

I Bhutto, G Lutty - Molecular aspects of medicine, 2012 - Elsevier
There is a mutualistic symbiotic relationship between the components of the
photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris …