The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age‐related ocular diseases and other pathologies of the anterior and …
M Nita, A Grzybowski - Oxidative medicine and cellular …, 2016 - Wiley Online Library
The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …
have both beneficial and harmful role. We search the literature and current knowledge in the …
[HTML][HTML] The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target
DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …
[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …
is a major cause of blindness. Even while central visual acuity remains relatively well …
Injectable anti‐inflammatory supramolecular nanofiber hydrogel to promote anti‐VEGF therapy in age‐related macular degeneration treatment
Age‐related macular degeneration (AMD) is a major cause of visual impairment and severe
vision loss worldwide, while the currently available treatments are often unsatisfactory …
vision loss worldwide, while the currently available treatments are often unsatisfactory …
Retinal microglia: just bystander or target for therapy?
Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …
[HTML][HTML] Neovascular age-related macular degeneration: therapeutic management and new-upcoming approaches
Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive
retinal degenerative disease of the macula that affects elderly people and cause central …
retinal degenerative disease of the macula that affects elderly people and cause central …
[HTML][HTML] Soft drusen in age-related macular degeneration: biology and targeting via the oil spill strategies
CA Curcio - Investigative ophthalmology & visual science, 2018 - iovs.arvojournals.org
AMD is a major cause of legal blindness in older adults approachable through
multidisciplinary research involving human tissues and patients. AMD is a vascular …
multidisciplinary research involving human tissues and patients. AMD is a vascular …
[HTML][HTML] Mechanisms of age-related macular degeneration
J Ambati, BJ Fowler - Neuron, 2012 - cell.com
Age-related macular degeneration (AMD), a progressive condition that is untreatable in up
to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of …
to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of …
[HTML][HTML] Oxidative stress and antioxidants in age-related macular degeneration
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …
Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris …
There is a mutualistic symbiotic relationship between the components of the
photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris …
photoreceptor/retinal pigment epithelium (RPE)/Bruch's membrane (BrMb)/choriocapillaris …