Antischistosomal agents: state of art and perspectives
EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments
AC Mengarda, TC Silva, AS Silva, DB Roquini… - European Journal of …, 2023 - Elsevier
Infections caused by parasitic helminths rank among the most prevalent infections of
humans and animals. Toxocariasis, caused by nematodes of the genus Toxocara, is one of …
humans and animals. Toxocariasis, caused by nematodes of the genus Toxocara, is one of …
Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties
JA Rocha, NCS Rego, BTS Carvalho, FI Silva… - PloS one, 2018 - journals.plos.org
Schistosomiasis affects million people and its control is widely dependent on a single drug,
praziquantel. Computational chemistry has led to the development of new tools that predict …
praziquantel. Computational chemistry has led to the development of new tools that predict …
Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis
Schistosomiasis is one of the most important parasitic infections in terms of its negative
effects on public health and economics. Since praziquantel is currently the only drug …
effects on public health and economics. Since praziquantel is currently the only drug …
Pyrazoline derivatives as promising novel antischistosomal agents
CS Morais, AC Mengarda, FB Miguel, KB Enes… - Scientific Reports, 2021 - nature.com
Praziquantel is the only available drug to treat schistosomiasis, a parasitic disease that
currently infects more than 240 million people globally. Due to increasing concerns about …
currently infects more than 240 million people globally. Due to increasing concerns about …
Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni …
AC Mengarda, MP Silva, ME Cirino… - Phytotherapy …, 2021 - Wiley Online Library
Schistosomiasis is a widespread human parasitic disease currently affecting over 200
million people, particularly in poor communities. Chemotherapy for schistosomiasis relies …
million people, particularly in poor communities. Chemotherapy for schistosomiasis relies …
Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis
Background Treatment and control of schistosomiasis, one of the most insidious and serious
parasitic diseases, depend almost entirely on a single drug, praziquantel. Since the funding …
parasitic diseases, depend almost entirely on a single drug, praziquantel. Since the funding …
Promethazine Exhibits Antiparasitic Properties In Vitro and Reduces Worm Burden, Egg Production, Hepatomegaly, and Splenomegaly in a Schistosomiasis Animal …
DB Roquini, RM Cogo, AC Mengarda… - Antimicrobial agents …, 2019 - Am Soc Microbiol
The treatment and control of schistosomiasis, a neglected disease that affects more than 200
million people worldwide, rely on the use of a single drug, praziquantel. A vaccine has yet to …
million people worldwide, rely on the use of a single drug, praziquantel. A vaccine has yet to …
Neolignans isolated from Saururus cernuus L. (Saururaceae) exhibit efficacy against Schistosoma mansoni
JR Brito, P Wilairatana, DB Roquini, BC Parra… - Scientific Reports, 2022 - nature.com
Schistosomiasis, a parasitic disease caused by the blood fluke of the genus Schistosoma,
affects over 230 million people, especially in developing countries. Despite the significant …
affects over 230 million people, especially in developing countries. Despite the significant …
Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni
R Porto, AC Mengarda, RA Cajas, MC Salvadori… - Pharmaceuticals, 2021 - mdpi.com
The intravascular parasitic worm Schistosoma mansoni is a causative agent of
schistosomiasis, a disease of great global public health significance. Praziquantel is the only …
schistosomiasis, a disease of great global public health significance. Praziquantel is the only …