Vascular smooth muscle cells in atherosclerosis

GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …

Vascular smooth muscle cells in atherosclerosis

MR Bennett, S Sinha, GK Owens - Circulation research, 2016 - Am Heart Assoc
The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that
aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced …

Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence

JC Wang, M Bennett - Circulation research, 2012 - Am Heart Assoc
Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions

R Virmani, FD Kolodgie, AP Burke, A Farb… - … , and vascular biology, 2000 - Am Heart Assoc
This review will reconsider the current paradigm for understanding the critical, final steps in
the progression of atherosclerotic lesions. That scheme, largely an outgrowth of …

Biodegradable nanoparticles for drug and gene delivery to cells and tissue

J Panyam, V Labhasetwar - Advanced drug delivery reviews, 2003 - Elsevier
Biodegradable nanoparticles formulated from poly (d, l-lactide-co-glycolide)(PLGA) have
been extensively investigated for sustained and targeted/localized delivery of different …

Vascular smooth muscle cell senescence promotes atherosclerosis and features of plaque vulnerability

J Wang, AK Uryga, J Reinhold, N Figg, L Baker… - Circulation, 2015 - Am Heart Assoc
Background—Although vascular smooth muscle cell (VSMC) proliferation is implicated in
atherogenesis, VSMCs in advanced plaques and cultured from plaques show evidence of …

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

GK Owens, MS Kumar… - Physiological reviews, 2004 - journals.physiology.org
The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease

MR Alexander, GK Owens - Annual review of physiology, 2012 - annualreviews.org
The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

Regulation of differentiation of vascular smooth muscle cells

GK Owens - Physiological reviews, 1995 - journals.physiology.org
The vascular smooth muscle cell (SMC) in mature animals is a highly specialized cell whose
principal function is contraction. The fully differentiated or mature SMC proliferates at an …

Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture

AC Newby - Physiological reviews, 2005 - journals.physiology.org
Intimal thickening, the accumulation of cells and extracellular matrix within the inner vessel
wall, is a physiological response to mechanical injury, increased wall stress, or chemical …