Purpose of review Antibody-mediated rejection is the leading cause of deterioration of graft
function and graft loss after kidney transplantation. Recent studies have reported an …

Hypertension and chronic kidney disease are more common in men than in premenopausal
women at the same age. In animal models, females are relatively protected against genetic …

Abstract Background Acute Kidney Injury (AKI), a common complication of acute coronary
syndromes (ACS), is associated with higher mortality and longer hospital stays. The role of …

ABSTRACT Introduction: Endothelin-1 (ET-1) is the most potent vasoconstrictor, and is
involved in the renal regulation of salt and water homeostasis. When produced in excess in …

The peptide hormone endothelin-1 and its receptors are linked to several disease states.
Pharmacological inhibition of this pathway has proven beneficial in pulmonary hypertension …

Renal preglomerular arterioles regulate vascular tone to ensure a large pressure gradient
over short distances, a function that is extremely important for maintaining renal …

Microvascular dysfunction (MVD) contributes to several conditions that increase morbidity
and mortality, including ischemic heart disease, heart failure, dementia, chronic kidney …

Renal endothelin-converting enzyme (ECE)-1 is induced in experimental diabetes and
following radiocontrast administration, conditions characterized by renal hypoxia, hypoxia …

Kidneys have an important role in regulating water volume, blood pressure, secretion of
hormones and acid-base and electrolyte balance. Kidney dysfunction derived from acute …

The amiloride-sensitive epithelial Na+ channel (ENaC) is a key player in the regulation of
Na+ homeostasis. Its functional activity is under continuous control by a variety of signaling …