Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies
This paper presents a meta-analysis of high-resolution human leukocyte antigen (HLA)
allele frequency data describing 497 population samples. Most of the datasets were …
allele frequency data describing 497 population samples. Most of the datasets were …
PyPop update–a software pipeline for large‐scale multilocus population genomics
Population genetic statistics from multilocus genotype data inform our understanding of the
patterns of genetic variation and their implications for evolutionary studies, generally, and …
patterns of genetic variation and their implications for evolutionary studies, generally, and …
Global diversity and evidence for coevolution of KIR and HLA
The killer immunoglobulin-like receptor (KIR) gene cluster shows extensive genetic diversity,
as do the HLA class I loci, which encode ligands for KIR molecules. We genotyped 1,642 …
as do the HLA class I loci, which encode ligands for KIR molecules. We genotyped 1,642 …
Current shifts and kin aggregation explain genetic patchiness in fish recruits
The scales of population structure in marine species depend on the degree to which larvae
from different populations are mixed in the plankton. There is an intriguing trend in marine …
from different populations are mixed in the plankton. There is an intriguing trend in marine …
Interindividual variability in response to continuous theta-burst stimulation in healthy adults
Objective We used complete-linkage cluster analysis to identify healthy subpopulations with
distinct responses to continuous theta-burst stimulation (cTBS). Methods 21 healthy adults …
distinct responses to continuous theta-burst stimulation (cTBS). Methods 21 healthy adults …
Juvenile idiopathic arthritis and HLA class I and class II interactions and age‐at‐onset effects
JA Hollenbach, SD Thompson… - Arthritis & …, 2010 - Wiley Online Library
Objective The aim of this study was to quantitate risk and to examine heterogeneity for HLA
at high resolution in patients with the most common subtypes of juvenile idiopathic arthritis …
at high resolution in patients with the most common subtypes of juvenile idiopathic arthritis …
Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population
DF Carr, M Chaponda, AL Jorgensen… - Clinical Infectious …, 2013 - academic.oup.com
Background. The nonnucleoside reverse transcriptase inhibitor nevirapine is the
cornerstone of treatment for human immunodeficiency virus (HIV) in many sub-Saharan …
cornerstone of treatment for human immunodeficiency virus (HIV) in many sub-Saharan …
HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China
E Trachtenberg, M Vinson, E Hayes, YM Hsu… - Tissue …, 2007 - Wiley Online Library
In this study, polymerase chain reaction‐sequence‐specific oligonucleotide prode (SSOP)
typing results for the human leukocyte antigen (HLA) class I (A, B, and C) and class II (DRB1 …
typing results for the human leukocyte antigen (HLA) class I (A, B, and C) and class II (DRB1 …
Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns
N Holland, C Furlong, M Bastaki… - Environmental …, 2006 - ehp.niehs.nih.gov
Recent studies have demonstrated widespread pesticide exposures in pregnant women and
in children. Plasma paraoxonase 1 (PON1) plays an important role in detoxification of …
in children. Plasma paraoxonase 1 (PON1) plays an important role in detoxification of …
Signatures of demographic history and natural selection in the human major histocompatibility complex loci
Many lines of evidence show that several HLA loci have experienced balancing selection.
However, distinguishing among demographic and selective explanations for patterns of …
However, distinguishing among demographic and selective explanations for patterns of …