[HTML][HTML] Hyperpolarized 13C MRI: path to clinical translation in oncology

J Kurhanewicz, DB Vigneron, JH Ardenkjaer-Larsen… - Neoplasia, 2019 - Elsevier
This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

Choline metabolism in malignant transformation

K Glunde, ZM Bhujwalla, SM Ronen - Nature Reviews Cancer, 2011 - nature.com
Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with
oncogenesis and tumour progression. Following transformation, the modulation of enzymes …

Challenges for molecular magnetic resonance imaging

E Terreno, DD Castelli, A Viale, S Aime - Chemical reviews, 2010 - ACS Publications
Challenges for Molecular Magnetic Resonance Imaging | Chemical Reviews ACS ACS
Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications. Most …

[HTML][HTML] Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research

J Kurhanewicz, DB Vigneron, K Brindle… - Neoplasia, 2011 - Elsevier
A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy

JH Ardenkjaer‐Larsen, GS Boebinger… - Angewandte Chemie …, 2015 - Wiley Online Library
In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to
brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when …

Chemistry and biochemistry of 13 C hyperpolarized magnetic resonance using dynamic nuclear polarization

KR Keshari, DM Wilson - Chemical Society Reviews, 2014 - pubs.rsc.org
The study of transient chemical phenomena by conventional NMR has proved elusive,
particularly for non-1H nuclei. For 13C, hyperpolarization using the dynamic nuclear …

NMR hyperpolarization techniques for biomedicine

P Nikolaou, BM Goodson… - Chemistry–A European …, 2015 - Wiley Online Library
Recent developments in NMR hyperpolarization have enabled a wide array of new in vivo
molecular imaging modalities, ranging from functional imaging of the lungs to metabolic …

15N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH

ML Truong, T Theis, AM Coffey… - The journal of …, 2015 - ACS Publications
NMR signal amplification by reversible exchange (SABRE) is a NMR hyperpolarization
technique that enables nuclear spin polarization enhancement of molecules via concurrent …

[图书][B] Magnetic resonance imaging of the brain and spine

SW Atlas - 2009 - books.google.com
Established as the leading textbook on imaging diagnosis of brain and spine disorders,
Magnetic Resonance Imaging of the Brain and Spine is now in its Fourth Edition. This …

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy

KM Brindle, SE Bohndiek, FA Gallagher… - Magnetic resonance …, 2011 - Wiley Online Library
Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …